World Vaccine Congress US 2025
July 21, 2025
Summary:
- Protective immunity depends not just on antibody titers, but also on Fc effector functions that engage the immune system through phagocytosis, cytotoxicity, and complement activation.
- Fc-mediated functions play a critical role in differentiating antibody quality, helping explain protection in the absence of high titers or neutralization.
- Comprehensive profiling across diverse immune cell types provides a more accurate understanding of efficacy and safety for both vaccine candidates and therapeutic antibodies.
- SeromYx’s high-throughput, antigen-specific assays and computational analytics offer powerful tools to identify correlates of protection and guide candidate selection.
Authors:
Lenny Moise, PhD.
Authors: Stefanutti E, Ramani R, Whitener B, Dang H, Bélanger S, Somasundaram L, Cortina K, De Marco A, Tam T, Chai Q, Cameroni E, Gupta R, Schmid MA, Miller JL, Zumsteg AB, Purcell LA, Drewry LL. 0. Analysis of Fc-dependent effector functions of anti-malaria circumsporozoite protein antibodies. Microbiol Spectr 0:e00863-25. Journal: Microbiology Spectrum
Antibody Engineering & Therapeutics 2025
The World Vaccine Congress Europe 2025
Festival of Biologics
The Fc-Mediated Effector Function Summit
Authors: Kaplonek P, et al. Sci Transl Med. 2022 May 18;14(645):eabm2311.
Authors: Hawman, David W. et al. eBioMedicine, Volume 115, 105698
Authors: Crescioli, S, Jatiani, S, & Moise, L, (2025). mAbs, 17(1). Journal: mAbs
Authors: Osborn, G., López-Abente, J., Adams, R. et al.
Woburn, MA / Newark, DE – October 1st, 2024 - SeromYx Systems, a cutting-edge immunology technology company, and ACROBiosystems, a leading provider for life science solutions and tools, are excited to announce the release of their joint study on the...
