World Vaccine Congress US 2025
July 21, 2025
Summary:
- Protective immunity depends not just on antibody titers, but also on Fc effector functions that engage the immune system through phagocytosis, cytotoxicity, and complement activation.
- Fc-mediated functions play a critical role in differentiating antibody quality, helping explain protection in the absence of high titers or neutralization.
- Comprehensive profiling across diverse immune cell types provides a more accurate understanding of efficacy and safety for both vaccine candidates and therapeutic antibodies.
- SeromYx’s high-throughput, antigen-specific assays and computational analytics offer powerful tools to identify correlates of protection and guide candidate selection.
Authors:
Lenny Moise, PhD.
SITC - Society for Immunotherapy and Cancer 2025
Authors: Chenoweth, A. M., et al. (2025). An Fc-engineered glycomodified antibody supports proinflammatory activation of immune effector cells and restricts progression of breast cancer. Cancer Research. Journal: Cancer Research
Authors: Rumyantsev, A., et al. (2025). Safety and immunogenicity of UB-612 heterologous booster: A pivotal Phase 3 study. eClinicalMedicine, The Lancet. Journal: The Lancet
Authors: Stefanutti E, Ramani R, Whitener B, Dang H, Bélanger S, Somasundaram L, Cortina K, De Marco A, Tam T, Chai Q, Cameroni E, Gupta R, Schmid MA, Miller JL, Zumsteg AB, Purcell LA, Drewry LL. 0. Analysis of Fc-dependent effector functions of anti-malaria circumsporozoite protein antibodies. Microbiol Spectr 0:e00863-25. Journal: Microbiology Spectrum
Antibody Engineering & Therapeutics 2025
The Fc-Mediated Effector Function Summit
Authors: Kaplonek P, et al. Sci Transl Med. 2022 May 18;14(645):eabm2311.
Authors: Hawman, David W. et al. eBioMedicine, Volume 115, 105698
Authors: Crescioli, S, Jatiani, S, & Moise, L, (2025). mAbs, 17(1). Journal: mAbs
Authors: Osborn, G., López-Abente, J., Adams, R. et al.
