Festival of Biologics
June 2, 2025
Festival of Biologics
Type: Conference
Dates: September 30th - October 2nd
Location:
Basel, Switzerland
Join us at Europe’s premier biologics conference, bringing together over 3,000 professionals from pharma, biotech, academia, and investment sectors. With 350+ speakers and 150+ exhibitors, the event covers the full spectrum of biologics—from early-stage discovery and antibody engineering to clinical trials, manufacturing, and commercialization. This is the ideal platform to explore the latest advancements in antibody therapies, cell and gene therapies, immunotherapies, and biosimilars.
Join us at our presentation
Title: Fc-mediated Functional Profiling to Derisk Candidate Selection of Therapeutic Antibodies
Date: September 30th at 1:50-2:10pm
Location: Theater 7
Abstract:
The arena of therapeutic antibodies is led by monoclonal antibodies (mAbs), bispecifics (BsAbs) and antibody drug conjugates (ADCs) with more complex Fc-containing formats currently gaining clinical traction. Antigen targeting remains the focus of candidate selection, however, Fc-mediated functions of antibodies significantly impact clinical efficacy and safety. Most developmental pipelines only assess Fc functions mediated by a narrow set of effectors, namely, NK cells (ADCC), monocytes (ADCP), and complement (CDC), but do not consider other immune effectors such as macrophages, neutrophils, basophils, eosinophils, dendritic cells, and platelets. A comprehensive assessment of Fc mediated functions can enable data-driven lead selection and optimization to advance the most promising candidates into the clinic with confidence.
Authors: Rumyantsev, A., et al. (2025). Safety and immunogenicity of UB-612 heterologous booster: A pivotal Phase 3 study. eClinicalMedicine, The Lancet. Journal: The Lancet
Authors: Stefanutti E, Ramani R, Whitener B, Dang H, Bélanger S, Somasundaram L, Cortina K, De Marco A, Tam T, Chai Q, Cameroni E, Gupta R, Schmid MA, Miller JL, Zumsteg AB, Purcell LA, Drewry LL. 0. Analysis of Fc-dependent effector functions of anti-malaria circumsporozoite protein antibodies. Microbiol Spectr 0:e00863-25. Journal: Microbiology Spectrum
Antibody Engineering & Therapeutics 2025
The World Vaccine Congress Europe 2025
The Fc-Mediated Effector Function Summit
Authors: Kaplonek P, et al. Sci Transl Med. 2022 May 18;14(645):eabm2311.
Authors: Hawman, David W. et al. eBioMedicine, Volume 115, 105698
Authors: Crescioli, S, Jatiani, S, & Moise, L, (2025). mAbs, 17(1). Journal: mAbs
Authors: Osborn, G., López-Abente, J., Adams, R. et al.
Woburn, MA / Newark, DE – October 1st, 2024 - SeromYx Systems, a cutting-edge immunology technology company, and ACROBiosystems, a leading provider for life science solutions and tools, are excited to announce the release of their joint study on the...
