A replicating RNA vaccine confers protection against CrimeanCongo hemorrhagic fever in cynomolgus macaques

Journal Abstract/ Summary: This study applied a high-throughput humoral immunoprofiling approach to better understand why some individuals with HIV naturally control the virus. By combining detailed biophysical and functional antibody assays, the researchers profiled antibody responses across individuals with different levels of viral control. Computational modeling then linked specific IgG features and effector functions, like complement activation and phagocytosis, to more effective immune responses. The findings highlight key antibody properties associated with viral suppression and offer a roadmap for designing more effective vaccines and antibody therapies.