Refining Lead Selection with Functional Precision

Go beyond neutralization, select leads based on what they actually do.

Even with identical Fc backbones, antibodies can show dramatically different effector profiles due to differences in epitope targeting and binding geometry. Broad Fc-function profiling across multiple assays (ADCC, ADNP, ADCD, and more) reveals subtle but actionable differences in activity. These insights help teams select lead candidates that best align with both the desired mechanism of action and pharmacokinetic goals.



• Identifies functional differences not explained by Fc engineering alone
• Supports lead selection based on mechanism-specific performance
• Balances effector activity with enhanced half-life (e.g., via YTE modification)