Comparative Immune Profiling Reveals Vaccine Functional Differences

Uncovering antibody mechanisms linked to protection beyond neutralization.

A head-to-head study of mRNA-1273 and BNT162b2 vaccines showed both induced strong humoral responses, but mRNA-1273 elicited higher IgA titers, enhanced Fcγ receptor binding, and greater functional activity (ADNP, ADNKA). Systems Serology mapped distinct Fc effector functions, offering mechanistic insights into their differing real-world efficacy and supporting identification of correlates of protection.



• Differentiates vaccine-induced functional antibody profiles linked to protection
• Detects spike-specific Fc activities beyond neutralization
• Provides mechanistic insight for clinical trial correlates and disease attenuation
  

Link