Optimizing Vaccine Lead Selection with Functional Insights

Prioritize candidates by protective antibody functions, not just quantity.

Systems Serology enables comparison of vaccine regimens based on their ability to elicit key protective antibody functions. Screening HIV vaccine candidates revealed wide variation in ADCP levels despite similar antibody titers. Changes in adjuvants and dosing shifted functional profiles, helping developers select candidates that induce higher-quality immune responses. This accelerates confident, data-driven down-selection for clinical advancement.

• Differentiates vaccine leads by antibody function, not just titer
• Reveals impact of formulation and regimen on immune quality
• Supports efficient selection of candidates with greater clinical potential
  

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