Discovering Early Immune Signatures in COVID-19

Systems Serology identifies antibody features linked to disease outcomes.

Profiling hospitalized COVID-19 patients revealed distinct antibody responses: survivors showed a spike (S)-focused, functional profile, while non-survivors had nucleocapsid (N)-biased, less effective antibodies. Just five key antibody features predicted clinical trajectory, supporting early risk stratification and biomarker development. These findings highlight the importance of spike-specific functional antibodies for vaccine targeting.

• Differentiates survivors and non-survivors using key antibody signatures
• Links enhanced S-specific phagocytosis and complement activity to protection
• Informs vaccine antigen selection and immune monitoring strategies
  

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